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MilliporeSigma

53340

Sigma-Aldrich

L-Histidine dihydrochloride

≥99.0% (AT)

Sinónimos:

L-Histidine hydrochloride (1:2)

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About This Item

Fórmula empírica (notación de Hill):
C6H9N3O2 · 2HCl
Número de CAS:
Peso molecular:
228.08
Beilstein/REAXYS Number:
6119230
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

L-Histidine dihydrochloride, ≥99.0% (AT)

assay

≥99.0% (AT)

form

powder or crystals

optical activity

[α]20/D +6.5±1°, c = 8% in H2O

ign. residue

≤0.1% (as SO4)

color

white

mp

240-245 °C (dec.)

solubility

H2O: soluble
saline: soluble

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

As: ≤0.1 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
NH4+: ≤500 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES string

Cl.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.2ClH/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);2*1H/t5-;;/m0../s1

InChI key

XEJCDBUNISUVGZ-XRIGFGBMSA-N

Biochem/physiol Actions

L-Histidine is a natural proteinogenic α amino acid useful as a cell growth supplement that support protein and peptide biosynthesis. L-Histidine is studied in a wide range of applications that involve imidazole chemistry and biochemisty.
L-Histidine is a positively charged imidazole-side chain containing α amino acid. It is metabolized to histamine and is a precursor of the dipeptide carnosine. As one of the 22 proteinogenic amino acids L-His is incorporated into proteins by translation processes in vitro. L-Histidine is an essential amino acid added to cell culture media.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificados de análisis (COA)

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Kirsten Jung et al.
Current opinion in microbiology, 15(2), 118-124 (2011-12-17)
Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how
Sadao Wakabayashi et al.
Seminars in thrombosis and hemostasis, 37(4), 389-394 (2011-08-02)
Histidine-rich glycoprotein (HRG) is one of the major plasma proteins and thought to function in blood coagulation, fibrinolysis, and innate immune systems. The amino acid sequence of HRG revealed a multidomain structure consisting of cystatin-like domains 1 and 2, a
Ana Reis et al.
Analytical and bioanalytical chemistry, 399(8), 2779-2794 (2011-02-01)
The radical oxidation of isomeric peptides containing one reactive amino acid [histidine (H)] and another less reactive amino acid [glycine (G)] in the form of dipeptides (HG and GH) and tripeptides (HGG, GHG, and GGH) was studied by mass spectrometry
Amir Abbas Farshid et al.
Indian journal of pharmacology, 45(2), 126-129 (2013-05-30)
Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) administration of vitamin C
Alan R Hipkiss
Journal of Alzheimer's disease : JAD, 11(2), 229-240 (2007-05-25)
Reactive oxygen species, reactive nitrogen species, copper and zinc ions, glycating agents and reactive aldehydes, protein cross-linking and proteolytic dysfunction may all contribute to Alzheimer's disease (AD). Carnosine (beta-alanyl-L-histidine) is a naturally-occurring, pluripotent, homeostatic agent. The olfactory lobe is normally

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