380R-2

Arginase-1 (EP261) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203

Propiedades

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP261, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (380R-24); vial of 0.1 mL concentrate Research Use Only (380R-24-RUO); vial of 0.5 mL concentrate (380R-25); vial of 1.0 mL concentrate (380R-26); vial of 1.0 mL concentrate Research Use Only (380R-26-RUO); vial of 1.0 mL pre-dilute Research Use Only (380R-27-RUO); vial of 1.0 mL pre-dilute ready-to-use (380R-27); vial of 7.0 mL pre-dilute ready-to-use (380R-28); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (380R-28-RUO)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 (concentrated)
• isotype: IgG
• control: hepatocellular carcinoma, normal liver
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic, nuclear
• Gene Information: human ... ARG1(383)

Descripción

General description

Arginase-1 is a key urea cycle metalloenzyme that has demonstrated expression in normal human liver with a high degree of specificity. Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver accounting for an estimated 70%-85% of total liver cancers worldwide. Diagnostic pitfalls exist in the morphologic distinction of HCC from other hepatocellular and non-hepatocellular lesions. In difficult or equivocal cases, the application of immunohistochemical (IHC) panels has been shown to aid in the distinction of benign and malignant liver lesions. In sections of normal liver, anti-arginase-1 produced strong, diffuse cytoplasmic reactivity in all hepatocytes throughout the lobule. In some cases, patchy nuclear reactivity is also evident in hepatocytes along with the cytoplasmic reactivity. Reactivity is not observed in bile duct epithelial cells, sinusoidal endothelial cells, Kupffer cells, or vascular endothelial cells. In sections of HCC, anti-arginase-1 produces cytoplasmic or cytoplasmic plus nuclear reactivity.

Quality

IVD

IVD

IVD

RUO

Linkage

Arginase-1 Positive Control Slides, Product No. 380S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable