315R-1

PD-1 (EP239) Rabbit Monoclonal Primary Antibody

• Sinónimos: CD279, PD1, PDCD1, SLEB2, hPH-1, hSLE1, programmed cell death 1, programmed cell death protein 1, protein PD-1, systemic lupus erythematosus suseptibilitl 2
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP239, monoclonal
• description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (315R-14); vial of 0.1 mL concentrate Research Use Only (315R-14-RUO); vial of 0.5 mL concentrate (315R-15); vial of 1.0 mL concentrate (315R-16); vial of 1.0 mL concentrate Research Use Only (315R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (315R-17-RUO); vial of 1.0 mL predilute ready-to-use (315R-17); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (315R-18-RUO); vial of 7.0 mL predilute ready-to-use (315R-18)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)
• isotype: IgG
• control: lymph node, tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: cytoplasmic, membranous
• Gene Information: human ... PDCD1(5133)

Descripción

General description

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

Quality

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Linkage

PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable