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MilliporeSigma

PHR1542

Supelco

Moxifloxacin Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Moxifloxacin hydrochloride, 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydropyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C21H24FN3O4· HCl
Número de CAS:
Peso molecular:
437.89
Beilstein/REAXYS Number:
8377447
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. Y0000703
traceable to USP 1448606

API family

moxifloxacin

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(O)=O

InChI

1S/C21H24FN3O4.ClH/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H/t11-,16+;/m0./s1

InChI key

IDIIJJHBXUESQI-DFIJPDEKSA-N

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General description

Moxifloxacin Hydrochloride is an anti-infectious compound that belongs to the class of fluoroquinolone antibiotics. It is a well-known broad-spectrum antibiotic prescription medicine effective against a variety of Gram-positive and Gram-negative bacteria including the anaerobic type. It is an S,S-isomer with two chiral centers. It works by preventing the activity of various crucial enzymes involved in the replication, transcription, recombination, and repair of deoxyribonucleic acid in the bacteria such as DNA gyrase (topoisomerase II), topoisomerase IV. It finds its application in the treatment of various ocular and respiratory tract infections.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

Moxifloxacin Hydrochloride can be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by spectrophotometric, chromatographic, and electrochemical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0258 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Referencia del producto
Descripción
Precios

pictograms

Exclamation mark

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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Certificados de análisis (COA)

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Visite la Librería de documentos

Development and validation of spectrophotometric, atomic absorption and kinetic methods for determination of moxifloxacin hydrochloride
Abdellaziz LM and Hosny MM
Analytical Chemistry Insights, 6(3), ACI-S8090 (2011)
Electrochemical determination of antibacterial drug moxifloxacin hydrochloride using chloranil modified carbon paste electrode
Attia AK and El-Shal MA
Analytical and Bioanalytical Chemistry, 4(3), 213-224 (2012)
Validated spectrophotometric methods for the estimation of moxifloxacin in bulk and pharmaceutical formulations
Motwani SK, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 68(2), 250-256 (2007)
Enantiomeric purity assay of moxifloxacin hydrochloride by capillary electrophoresis
Cruz LA and Hall R
Journal of Pharmaceutical and Biomedical Analysis, 38(1), 8-13 (2005)
Review of moxifloxacin hydrochloride ophthalmic solution in the treatment of bacterial eye infections
Miller D
Clinical Ophthalmology (Auckland, N.Z.), 2(1), 77-77 (2008)

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