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MilliporeSigma

P7003

Supelco

Piperazine hexahydrate

analytical standard

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About This Item

Fórmula empírica (notación de Hill):
C4H10N2 · 6H2O
Número de CAS:
Peso molecular:
194.23
Beilstein/REAXYS Number:
4455527
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

vapor pressure

0.8 mmHg ( 20 °C)

assay

≥99% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

145-156 °C (lit.)

mp

42-44 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].C1CNCCN1

InChI

1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2

InChI key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

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General description

Piperazine hexahydrate may be used as a standard for the determination of piperazine in pharmaceutical preparations using colorimetric technique.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Health hazardCorrosion

signalword

Danger

Hazard Classifications

Repr. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 1

flash_point_f

190.4 °F - closed cup

flash_point_c

88 °C - closed cup


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Colorimetric determination of piperazine in pharmaceutical formulations
Dessouky M Y and Ismaiel A S.
Analyst, 99(1181), 482-486 (1974)
Juneha Bak et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(10), 1269-1274 (2020-06-23)
Sulfated saccharides exhibit diverse physiological activities, but a lack of any convenient assay hinders their evaluation. Herein, an assay for the analysis of sulfated saccharides is described using 1H nuclear magnetic resonance (NMR) spectroscopy by employing ligands that can form
P Krishnan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 379-385 (2012-12-12)
Monohydrate piperazine hydrogen phosphate (MPHP), a semi organic nonlinear optical material has been synthesized and single crystals were grown from aqueous solution by slow evaporation technique. Single crystal X-ray diffraction study on grown crystal reveals that they belong to monoclinic
Jadwiga Handzlik et al.
Bioorganic & medicinal chemistry, 20(14), 4245-4257 (2012-06-29)
The study is focused on a series of 5-arylidenehydantoin derivatives with a phenylpiperazine-hydroxypropyl fragment at N3 of the hydantoin ring. The compounds were assessed on their affinity for α(1)-adrenoceptors and evaluated in functional bioassays for their antagonistic properties. Crystal structures
Enza Lacivita et al.
Journal of medicinal chemistry, 55(14), 6375-6380 (2012-06-29)
Here we report the design, synthesis, and 5-HT(7) receptor affinity of a set of 1-(3-biphenyl)- and 1-(2-biphenyl)piperazines. The effect on 5-HT(7) affinity of various substituents on the second (distal) phenyl ring was analyzed. Several compounds showed 5-HT(7) affinities in the

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