I3377

Isoniazid

analytical standard, ≥99% (TLC)

• Sinónimos: 4-Pyridinecarboxylic acid hydrazide, INH, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Fórmula empírica (notación de Hill): C₆H₇N₃O
• Número de CAS: 54-85-3
• Peso molecular: 137.14
• Beilstein/REAXYS Number: 119374
• EC Number: 200-214-6
• MDL number: MFCD00006426
• UNSPSC Code: 41116107
• PubChem Substance ID: 329815370
• NACRES: NA.24

Propiedades

• grade: analytical standard
• Quality Level: 100
• assay: ≥99% (TLC)
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 171-173 °C (lit.)
• fluorescence: λ_ex 360 nm; λ_em 450 nm (thiol adduct)
• antibiotic activity spectrum: mycobacteria
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• SMILES string: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• InChI key: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Descripción

General description

Chemical structure: pyridine

Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Recommended products

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Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Oral - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves