Saltar al contenido
MilliporeSigma

B5887

Sigma-Aldrich

Sodium butyrate

≥98.5% (GC)

Sinónimos:

Butyric acid sodium salt

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Fórmula lineal:
CH3CH2CH2COONa
Número de CAS:
Peso molecular:
110.09
Beilstein/REAXYS Number:
3629439
EC Number:
MDL number:
UNSPSC Code:
12352107
PubChem Substance ID:
NACRES:
NA.25

biological source

synthetic (organic)

Quality Level

assay

≥98.5% (GC)

form

powder

storage condition

(Tightly closed. Dry.
Keep in a dry place. )

technique(s)

DNA amplification: suitable
cell based assay: suitable
inhibition assay: suitable

color

white

mp

250-253 °C (lit.)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless

cation traces

Na: 19.8-22.0% (anhydrous)

suitability

suitable for DNA precipitation

application(s)

cell analysis
life science and biopharma
lipidomics

storage temp.

room temp

SMILES string

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

InChI key

MFBOGIVSZKQAPD-UHFFFAOYSA-M

Gene Information

¿Está buscando productos similares? Visita Guía de comparación de productos

Application

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Biochem/physiol Actions

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

Caution

Hygroscopic

Other Notes

For additional information on our range of Biochemicals, please complete this form.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Jiangping He et al.
Nature communications, 10(1), 34-34 (2019-01-04)
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full
Joanna Jaworska et al.
Molecular neurobiology, 56(9), 6341-6370 (2019-02-16)
Neonatal hypoxic-ischemic (HI) brain injury likely represents the major cause of long-term neurodevelopmental disabilities in surviving babies. Despite significant investigations, there is not yet any known reliable treatment to reduce brain damage in suffering infants. Our recent studies in an

Artículos

Naive pluripotent stem cells are located within the epiblast of mature blastocysts. These primitive “ground-state” cells may be cultured in vitro using specialized media and small molecule inhibitors.

Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico