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Key Documents

48912-U

Sigma-Aldrich

ProClin™ 300

pkg of 50 mL, ProClin™ preservative for use in IVD manufacturing, CMIT/MIT 3 %

Sinónimos:

3% solution of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-Methyl-4-isothiazolin-3-one

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.21

form

liquid

shelf life

3 yr

contains

Alkyl Carboxylate

composition

CMIT/MIT, 3%

packaging

pkg of 50 mL

parameter

<45 °C operating temperature

color

colorless to light yellow

matrix

Modified glycol

operating pH range

2.5-8.5

pH

4.1 (100 g/L)

bp

189 °C

mp

-40 °C

solubility

water: soluble

density

1.03 g/cm3

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General description

ProClin™ preservatives are water-soluble preparations of biocides that are generally used to increase the shelf life of reagents. ProClin™ 300 comprises of 3% of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and 2-methyl-4-isothiazloin-3-one (MIT) in a salt-free proprietary glycol containing an alkly carboxylate stabilizer. It has a recommended working pH range as 2.5 - 8.5.

Application

For use in IVD Manufacturing
ProClin™ 300 is suitable for preparation of different buffers like ELISA buffer, sample and substrate dilution buffers for Single-Molecule Arrays (Simoa assay) and Immunoenzymatic assay. Additionally, Proclin™ may be used in preparing storage buffer to store beads coupled with coronavirus nucleocapsid protein for the serological multiplex assay.
ProClin™ biocides preservatives are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin™ toxicity prevent microorganisms from developing high levels of resistance, making ProClin™ highly efficient even over extended storage periods of your IVD components.

Biochem/physiol Actions

ProClin™ products contain active substances like CMIT and MIT which inhibit the Krebs cycle at four different check points, the enzymes pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, succinate dehydrogenase, and NADH dehydrogenase. The inhibition of Krebs cycle leads to effective broad-spectrum biocidal activity against bacteria, fungi, and yeast.

Legal Information

ProClin is a trademark of LANXESS Corp.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada′s Pest Management Regulatory Agency, Turkey′s Biocidal Products Regulation, Korea′s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

244.4 °F - closed cup

flash_point_c

118 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
MKCP9992
MKCP7878
MKCP6266
MKCP3008
MKCP4081

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