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37011

Supelco

Methazolamide

VETRANAL®, analytical standard

Sinónimos:

5-Acetylimino-4-methyl-·2-1,3,4-thiadiazoline-2-sulfonamide, N-(4-Methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene) acetamide, L 584601, N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide

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About This Item

Fórmula empírica (notación de Hill):
C5H8N4O3S2
Número de CAS:
554-57-4
Peso molecular:
236.27
EC Number:
209-066-7
MDL number:
MFCD00083416
UNSPSC Code:
41116107
PubChem Substance ID:
329755575

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

208 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

CN1N=C(S\C1=N\C(C)=O)S(N)(=O)=O

InChI

1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+

InChI key

FLOSMHQXBMRNHR-QPJJXVBHSA-N

Gene Information

human ... CA1(759) , CA2(760) , CA4(762) , CA7(766)

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number
BCCG2707
BCCB4134
BCCB1558
BCBS6990V
BCBS4818V

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Journal of refractive surgery (Thorofare, N.J. : 1995), 27(1), 70-73 (2010-06-15)
to report the successful treatment of two patients who developed flap necrosis preceded by recurrent epithelial ingrowth and interface fluid syndrome after LASIK. patient 1 was treated with epithelial debridement and flap suturing. Patient 2 was initially treated with epithelial
Harold J Bell et al.
Respiratory physiology & neurobiology, 171(3), 201-211 (2010-04-13)
The typical respiratory response to hypoxia includes a dramatic facilitation of augmented breaths (ABs) or 'sighs' in the breathing rhythm. We recently found that when acetazolamide treatment is used to promote CO(2) retention and counteract alkalosis during exposure to hypoxia
A novel medication error in the treatment of hyperthyroidism.
Bhavesh B Barad et al.
Tennessee medicine : journal of the Tennessee Medical Association, 106(2), 42-42 (2013-03-20)
Mohamed G Hassan et al.
Biomedical chromatography : BMC, 26(2), 214-219 (2011-05-20)
A sensitive high-performance liquid chromatographic method with fluorescence detection was developed to determine memantine (MT) in rat plasma. The method consists of pre-column labeling of MT with 4-(4,5-diphenyl-1H-imidazol-2-yl)benzoyl chloride (DIB-Cl) and a clean-up step with solid-phase extraction. A good separation
Phatsawee Jansook et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76(2), 208-214 (2010-07-20)
Topically applied carbonic anhydrase inhibitors (CAIs) are commonly used to treat glaucoma. However, their short duration of action requiring multiple daily dosing can hamper patient compliance. The aim of this study was to develop novel aqueous CAI eye drop formulation
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