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32991

Supelco

Lanoconazole

VETRANAL®, analytical standard

Sinónimos:

2-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile

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About This Item

Fórmula empírica (notación de Hill):
C14H10ClN3S2
Número de CAS:
101530-10-3
Peso molecular:
319.83
MDL number:
MFCD00865590
UNSPSC Code:
41116107
PubChem Substance ID:
329754426
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

Clc1ccccc1C2CS\C(S2)=C(\C#N)n3ccnc3

InChI

1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12+

InChI key

ZRTQSJFIDWNVJW-WYMLVPIESA-N

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General description

Lanoconazole is a member of the imidazole family and an antifungal agent, which finds applications as an antidermatophytic drug.

Application

Lanoconazole may be used as a reference standard in the determination of lanoconazole in pharmaceutical formulations using high-performance liquid chromatography coupled with an ultraviolet detector (HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCG1057
BCCC4640
BCBV5216

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Y Niwano et al.
Arzneimittel-Forschung, 47(9), 1056-1060 (1997-10-29)
To answer the question why topically applied lanoconazole (CAS 101530-10-3, NND-318) is so highly effective in the treatment of dermatomycoses in both animal models and human patients, the antifungal activity of lanoconazole in infected sites was investigated. 1. Distribution of
Shigehiro Hagiwara et al.
Mycopathologia, 184(1), 13-21 (2018-10-07)
Aspergillus species are the most common pathogenic fungi involved in otomycosis, an infection of the outer ear canal. In this study, we examined the incidence of Aspergillus infections and the antifungal susceptibilities of 30 Aspergillus species isolates from patients with
M A Ghannoum et al.
Medical mycology, 48(3), 491-497 (2010-04-08)
The in vivo efficacy of terbinafine was compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model. Topical antifungal treatment commenced three days post-infection, and each agent was applied once
H Tanuma et al.
Mycoses, 44(5), 181-190 (2001-08-07)
Hyperkeratotic type tinea pedis is a refractory type of superficial dermatomycosis. Treatment for hyperkeratotic type tinea pedis is mainly with oral antimycotics, such as griseofulvin, and healing is generally considered to be difficult with only topical antimycotics. In this randomized
Yukio Oku et al.
Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology, 43(3), 181-187 (2002-07-30)
The fungicidal activities of thiocarbamate antifungal agent liranaftate were studied by determining the MIC and the MCC against Trichophyton rubrum with the Milliflex -100 Test System and by determining the time-kill curve in comparison to that of six reference agents.
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