MABN742

Anti-Neuroligin-1, clone 1C9.1 Antibody

clone 1C9.1, from mouse

• Sinónimos: neuroligin 1, NLGN1, neuroligin-1
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• biological source: mouse
• Quality Level: 100
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 1C9.1, monoclonal
• species reactivity: human, rat
• technique(s): immunohistochemistry: suitable; western blot: suitable
• isotype: IgG2aκ
• NCBI accession no.: NP_055747
• UniProt accession no.: Q8N2Q7
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... NLGN1(22871)

Descripción

General description

Neuroligin-1 is a neuronal cell surface protein belonging to the type-B carboxylesterase/lipase family. It is a necessary component in the maturation of excitatory synapses for their normal, functional development, and is necessary to the regulation of synaptic plasticity and the development of long-term memory within the adult amygdala in mammals. It is believed to participate in cell-cell-interaction through the assembly of intracellular junction by the binding of beta-neurexins, and may also be a factor in the maintenance and assembly of synaptic junctions. It is also thought to have involvement in excitatory synaptic specification. Within brain tissue, Neuroligin-1 is primarily observed in neurons and spinal cord.

Immunogen

Epitope: Extracellular domain

GST-tagged recombinant protein corresponding to the extracellular domain of Human Neuroligin-1.

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Neuroligin-1 in human cerebral cortex, rat cerebellum and rat cerebral cortex tissue.

Research Category
Neuroscience

Neuroscience

Research Sub Category
Synapse & Synaptic Biology

Growth Cones & Axon Guidance

This Anti-Neuroligin-1, clone 1C9.1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of Neuroligin-1.

Quality

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Neuroligin-1 in 10 µg of rat brain tissue lysate.

Target description

~94 kDa observed

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable