ABN326

Anti-CAPS-2 Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Calcium-dependent secretion activator 2, CADPS2, CAPS-2
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human, mouse, rat
• technique(s): immunohistochemistry: suitable; western blot: suitable
• UniProt accession no.: Q86UW7
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... CAPS2(84698)

Descripción

General description

CAPS-2 and the related protein CAPS-1 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficient neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. Like CAPS-1, numerous isoforms of CAPS-2 are known to exist. These isoforms show distinct expression patterns in the brain. For example, CAPS2b showed high expression in the developing cerebellum. Furthermore, one version of CAPS-2 mRNA that lacks exon 3 is detected in some autistic patients, suggesting that the differential expression pattern of CAPS-2 is involved in neuronal development.

Specificity

This antibody is predicted to be specific to CAPS-2 and not recognize CAPS-1.

Immunogen

KLH-conjugated linear peptide corresponding to human CAPS-2.

Application

Anti-CAPS-2 detects levels of CAPS-2 proteins & has been published & validated for use in WB & IHC.

Western Blot Analysis: 1 µg/mL from a representative lot detected CAPS-2 in 10 µg/mL of human brain tissue lysate.

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected CAPS-2 in rat cerebellum tissue.

Quality

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected CAPS-2 in 10 µg/mL of mouse brain tissue lysate.

Target description

~160 kDa observed. Uncharacterized bands may appear at ~40 kDa, ~50 kDa, and ~210 kDa in some lysates.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable