8.55117
Hydroxylamine Wang resin
Novabiochem®
Sinónimos:
Amino-oxy Wang resin
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About This Item
UNSPSC Code:
12352116
NACRES:
NA.22
Productos recomendados
Quality Level
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-8°C
Categorías relacionadas
General description
An excellent support for the preparation of peptide hydroxamic acids [1] by Fmoc SPPS. Acylation of the resin has been carried out using TBTU/DIPEA activation [1]. Alkylation of the resin-bound nitrogen has been effected using TMOF/DCE/AcOH for imine formation, followed by reduction with BH3-pyridine [2], by base-mediated alkylation of the N-Boc-protected hydroxylamine, followed by Boc removal with 20% TFA in DCM [3], or by Michael-addition [4]. Cleavage of hydroxamates from the resin has been effected with TFA/DCM/water (70:28:2) [1] or TFA/DCM (1:1) [2]. Hydroxylamine Wang resin has also been utilized to prepare tertiary amines by base-mediated elimination of the quaternized polymer-bound hydroxylamine [3, 5].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.
Linkage
Replaces: 01-64-0454
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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