8.55012
Trityl chloride resin
Novabiochem®
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
UNSPSC Code:
12352101
Productos recomendados
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
2-30°C
General description
An acid-labile resin for the solid phase immobilization of alcohols [1,2,3,4,5], amines [4, 6,7,8,9,10,11,12], sugars [13], O- and N-linked hydroxylamines [14,15], imidazoles [16] and carboxylic acids [16]. Release of these functionalities is generally achieved using 1-5% TFA in DCM containing 5% TIS. Amines can also be cleaved with 30% HFIP in DCM [4]. This resin, although very acid sensitive, can also be used in peptide synthesis [17].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] C. C. Leznoff (1978) Acc. Chem. Res., 11, 327.
[2] C. Chen, et al. (1994) J. Am. Chem. Soc., 116, 2661.
[3] Z. Li & A. Ganesan (1998) Syn. Lett., 405.
[4] P. Athanassopoulos, et al., Poster 316 presented at the 24thEuropean Peptide Symposium, Edinburgh, 1996.
[5] K. Barlos, et al. (1988) Liebigs Ann. Chem., 1079.
[6] K. Barlos, et al. in ′Peptides 1992, Proc. 22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden,1993, pp. 281.
[7] M. Schuster, et al. (1996) Angew. Chem. Int. Ed. Engl., 35, 1979.
[8] P. Garibay, et al. (1998) Tetrahedron Lett., 39, 2207.
[9] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
[10] S. Manku, et al. (2001) J. Org. Chem., 66, 874.
[11] D. Jönsson, et al. (2001) Tetrahedron Lett., 42, 6953.
[12] C. A. Olsen, et al. (2003) Org. Lett., 5, 4183.
[13] F. Peri, et al. (2000) Tetrahedron Lett., 41, 8587.
[14] U. Bauer, et al. (1997) Tetrahedron Lett., 38, 7233.
[15] O. Kinzel, et al. (2003) J. Peptide Sci., 9, 375.
[16] D. P. Matthews, et al. (2000) J Comb. Chem., 2,19.
[17] K. Barlos, et al. (1989) Tetrahedron Lett., 30, 3943.
Linkage
Replaces: 01-64-0074
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Ala-Leu loaded resin): 1.1 - 1.7 mmol/g
Swelling Volume (in CH₂Cl₂): lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 200 - 400 mesh
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico