557502

Ro-20-1724

≥98% (TLC), solid, cAMP phosphodiesterase inhibitor, Calbiochem

• Sinónimos: Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
• Fórmula empírica (notación de Hill): C₁₅H₂₂N₂O₃
• Número de CAS: 29925-17-5
• Peso molecular: 278.35
• MDL number: MFCD00077397
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• product name: Ro-20-1724, A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).
• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: DMSO: 20%; ethanol: 4%
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
• InChI key: PDMUULPVBYQBBK-UHFFFAOYSA-N

Descripción

General description

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PDE IV

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 µM against PDE IV

Warning

Toxicity: Irritant (B)

Other Notes

Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable