420355

Isoprenaline hydrochloride

≥99% (TLC), solid, β-adrenoceptor agonist, Calbiochem

• Sinónimos: Isoproterenol, Hydrochloride
• Fórmula empírica (notación de Hill): C₁₁H₁₇NO₃ · xHCl
• Número de CAS: 51-30-9
• Peso molecular: 211.26 (free base basis)
• MDL number: MFCD00012603
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• product name: Isoproterenol, Hydrochloride, Phenethylamine derivative.
• Quality Level: 100
• assay: ≥99% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to off-white; white
• solubility: ethanol: soluble; water: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
• InChI key: IROWCYIEJAOFOW-UHFFFAOYSA-N

Descripción

General description

Phenethylamine derivative. Selective β-adrenergic agonist that increases cytosolic cAMP. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^- diffusion and potential difference in rabbit trachea cells through nitric oxide generation.

Phenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^– diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.

Biochem/physiol Actions

Cell permeable: no

Primary Target
β-adrenergic agonist

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Other Notes

Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem.275, 25342.
Carmena, M.J., et al. 1997. Prostate 33, 46.
Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
Kishimoto, I., et al. 1994. J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994. Mol. Cell Biochem.141, 27.
Yashiro, K., et al. 1994. J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993. J. Neurochem.60, 260.
von Zastrow, M., et al. 1993. J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable