317641

Dipeptidylpeptidase IV Inhibitor III

The Dipeptidylpeptidase IV Inhibitor III, also referenced under CAS 866396-34-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Sinónimos: Dipeptidylpeptidase IV Inhibitor III, 1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
• Fórmula empírica (notación de Hill): C₁₄H₂₀N₄O₂ · xHCl
• Número de CAS: 866396-34-1
• Peso molecular: 276.33 (free base basis)
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: PBS: 20 mg/mL; ethanol: 20 mg/mL; water: 20 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Descripción

General description

An orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC₅₀ = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Wright, S.W., et al. 2006. J. Med. Chem.49, 3068.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable