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Documentos clave

19-130

Sigma-Aldrich

Okadaic Acid (sodium salt)

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About This Item

UNSPSC Code:
12352106
eCl@ss:
32160405
NACRES:
NA.41
grade:
for analytical purposes
form:
solid

grade

for analytical purposes

Quality Level

100

form

solid

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

shipped in

wet ice

Application

Suitable for use as an inhibitor of serine/threonine-specific protein phosphatases.

Quality

Routinely evaluated as an inhibitor in a kinase assay.

Storage and Stability

Lyophilized: 2 years at 4°C; Rehydrated: 6 months at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Skin Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

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The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2.
Redpath, N T and Proud, C G
The Biochemical Journal, 262, 69-75 (1989)
Simian virus 40 small tumor antigen inhibits dephosphorylation of protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Wheat, W H, et al.
Molecular and cellular biology, 14, 5881-5890 (1994)
F M Amara et al.
The Journal of biological chemistry, 271(33), 20126-20131 (1996-08-16)
Mammalian ribonucleotide reductase is a highly regulated activity essential for DNA synthesis and repair. The 3'-untranslated region (3'-UTR) of mammalian ribonucleotide reductase R2 mRNA has been implicated in the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate-mediated stabilization of mouse BALB/c 3T3 R2 message. We
Okadaic acid. Protein phosphatase inhibition and muscle contractile effects.
Takai, A
Journal of Muscle Research and Cell Motility, 9, 563-565 (1988)
E G Mimnaugh et al.
The Journal of biological chemistry, 270(48), 28654-28659 (1995-12-01)
The abundant, cytoplasmic 90-kDa heat-shock protein associates transiently with the Rous sarcoma virus oncogenic protein tyrosine kinase, pp60v-src, directs its cellular trafficking and negatively regulates its kinase activity. Here we report that the serine/threonine phosphatase inhibitor, okadaic acid, destabilized the
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