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Key Documents

189725

Sigma-Aldrich

Avidin, Egg White

Sinónimos:

Avidin, Egg White

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About This Item

Número de CAS:
MDL number:
UNSPSC Code:
41116133
NACRES:
NA.41

form

lyophilized solid

Quality Level

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

dilute buffer: 5 mg/mL
distilled water: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Avidin is a tetrameric glycoprotein and an anti-nutrient found in the eggs of all oviparous vertebrates. It constitutes 0.05–0.5% of the total protein in hen eggs. Avidin structure contains eight orthogonal antiparallel β-strands, a single disulfide bond, and a carbohydrate side chain.

Application

Avidin, Egg White has been used as a blocking agent in protein-binding assays. It has also been used to form avidin-biotin linkage to conjugate gemcitabine onto microbubbles for drug delivery to in vivo model.

Biochem/physiol Actions

Avidin can be used as a label for antibodies, fluorescent dyes, proteins,, and other molecules of interest to biochemists. The high binding affinity of avidin to biotin (vitamin H) causes the unavailability of biotin to microorganisms, which leads to the inhibition of their proliferation. This feature of avidin contributes to its antimicrobial property and affects biotin absorption in the body, resulting in vitamin B7 deficiency.

Warning

Toxicity: Standard Handling (A)

Unit Definition

One unit is defined as the amount of avidin that will bind 1 µg D-biotin at pH 8.9.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C. Avoid freeze/thaw cycles.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Visualizing structural changes of egg avidin to thermal and electric field stresses by molecular dynamics simulation
Zhu Y, et al.
LWT--Food Science and Technology, 151, 112139-112139 (2021)
Eva Krkavcová et al.
Biology open, 7(4) (2018-03-16)
Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is assumed to have a pronounced, though still poorly explored, effect on hatchling phenotype. We tested
Mu A et al.
Nature cell biology, 21(5), 592-602 (2019-04-10)
Inverted formin 2 (INF2) is a member of the formin family of actin assembly factors. Dominant missense mutations in INF2 are linked to two diseases: focal segmental glomerulosclerosis, a kidney disease, and Charcot-Marie-Tooth disease, a neuropathy. All of the disease

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