1.37159

DL-Ditiotreitol

EMPROVE^® ESSENTIAL

• Sinónimos: treo-1,4-dimercapto-2,3-butanediol, DTT, Reactivo de Cleland
• Fórmula lineal: HSCH₂CH(OH)CH(OH)CH₂SH
• Número de CAS: 3483-12-3
• Peso molecular: 154.25
• Beilstein/REAXYS Number: 1719757
• MDL number: MFCD00004877
• EC Index Number: 222-468-7

Propiedades

• biological source: synthetic
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• mp: 41-44 °C (lit.)
• application(s): pharma/biopharma processes
• storage temp.: −20°C (−15°C to −25°C)
• SMILES string: O[C@H](CS)[C@H](O)CS
• InChI: 1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m1/s1
• InChI key: VHJLVAABSRFDPM-QWWZWVQMSA-N

Descripción

General description

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.
M-Clarity Program
As part of our Emprove^® Program, our raw materials are offered with Emprove^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.
Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

DTT is an excellent reagent chemical used to reduce disulfide bonds commonly found in bioprocessing. DTT is used in buffer formulations to maintain and stabilize free -SH in applications such as protein based biotherapeutics and enzyme stability.

Un reactivo excelente para el mantenimiento de los grupos SH en estado reducido; reduce cuantitativamente los disulfuros. El DTT reduce de manera eficaz los enlaces disulfuro de las proteínas en tampones de muestra antes de la SDS-PAGE. El DTT puede utilizarse también para reducir el puente disulfuro del reticulante N,N′-bis(acriloil)cistamina con el fin de separar la matriz de un gel de poliacrilamida. El DTT es menos mordaz y menos tóxico que el 2-mercaptoetanol. Normalmente se requiere una concentración de DTT siete veces inferior (100 mM) a la concentración utilizada del 2-mercaptoetanol (5 % v/v, 700 mM).

Packaging

1.37159.0010 / 10 g / Amber glass bottle
1.37159.0100 / 100 g / Amber glass bottle
1.37159.1000 / 1 kg / LDPE bag with outer HDPE drum
1.37159.9010 / 10 kg / LDPE bag with outer HDPE drum

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC Pharma is a registered trademark of Sigma-Aldrich Co. LLC

Información de seguridad

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302 - H315 - H318
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable