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Key Documents

12-242

Sigma-Aldrich

Glycogen Synthase Peptide-2

Ala21, negative control for GSK-3β

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About This Item

UNSPSC Code:
12352204
eCl@ss:
32160405
NACRES:
NA.42

product name

Glycogen Synthase Peptide-2 (Ala21), Glycogen Synthase Peptide-2 (Ala21) primarily used in Kinase Assays.

Quality Level

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

UniProt accession no.

shipped in

wet ice

Quality

Routinely evaluated for use as a negative control for assay of GSK-3β (Catalog # 14-306) activity in a phosphorylation assay. Not to be used as a substrate for GSK3.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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S R Kimball et al.
The Journal of biological chemistry, 273(47), 30945-30953 (1998-11-13)
The present study was designed to investigate the mechanism through which leucine and histidine regulate translation initiation in L6 myoblasts. The results show that both amino acids stimulate initiation and coordinately regulate the activity of eukaryotic initiation factor eIF2B. The
Regulation and functions of the glycogen synthase kinase-3 subfamily.
Woodgett, J R
Seminars in cancer biology, 5, 269-275 (1994)
M P Coghlan et al.
Chemistry & biology, 7(10), 793-803 (2000-10-18)
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors, cell specification factors and cell adhesion. Consequently, inhibition of GSK-3 activity has been proposed to

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