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Key Documents

06-559

Sigma-Aldrich

Anti-Pyk2 Antibody

Upstate®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PTK2B(2185)

Specificity

Recognizes Pyk2, and its degradation products; does not cross-react with FAK.

Immunogen

GST-fusion protein containing amino acids 726-863 of human Pyk2

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling
This Anti-Pyk2 Antibody is validated for use in IC, IP, WB for the detection of Pyk2.

Quality

routinely evaluated by immunoblot on mouse brain cytosolic RIPA lysates

Target description

125 kDa

Physical form

Format: Purified
Protein A Purified immunoglobulin in 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Protein A purified

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Mouse brain cytosolic RIPA lysates

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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S Eguchi et al.
Hypertension (Dallas, Tex. : 1979), 33(1 Pt 2), 201-206 (1999-02-04)
-PYK2, a recently identified Ca2+-sensitive tyrosine kinase, has been implicated in extracellular signal-regulated kinase (ERK) activation via several G protein-coupled receptors. We have reported that angiotensin II (Ang II) induces Ca2+-dependent transactivation of the epidermal growth factor receptor (EGFR) which
Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
Younes, MN; Yigitbasi, OG; Yazici, YD; Jasser, SA; Bucana, CD; El-Naggar, AK; Mills, GB; Myers, JN
Archives of Otolaryngology--Head & Neck Surgery null
Rongfang Wei et al.
Cancer communications (London, England), 42(11), 1185-1206 (2022-08-31)
Multiple myeloma (MM) is the second most common hematological malignancy. An overwhelming majority of patients with MM progress to serious osteolytic bone disease. Aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) participates in several steps during cancer development and osteoclast differentiation. This
p21 as a transcriptional co-repressor of S-phase and mitotic control genes.
Ferrandiz, N; Caraballo, JM; Garcia-Gutierrez, L; Devgan, V; Rodriguez-Paredes, M; Lafita et al.
Testing null
Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Gore, Y; Lantner, F; Hart, G; Shachar, I
Molecular Biology of the Cell null

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