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Documentos clave

05-827

Sigma-Aldrich

Anti-Glucocorticoid Receptor Antibody, clone FIGR

clone FIGR, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
clone:
FIGR, monoclonal
application:
IP
WB
species reactivity:
hamster, mouse, rat
technique(s):
immunoprecipitation (IP): suitable
western blot: suitable
citations:
4

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

FIGR, monoclonal

species reactivity

hamster, mouse, rat

should not react with

human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_000176

UniProt accession no.

P04150

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... NR3C1(2908)

Specificity

glucocorticoid receptor

Immunogen

Native glucocorticoid receptor purified from rat liver

Application

Detect Glucocorticoid Receptor with Anti-Glucocorticoid Receptor Antibody, clone FIGR (Mouse Monoclonal Antibody), that has been shown to work in IP & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Quality

routinely evaluated by immunoblot on RIPA lysates from L6, PC12, and 3T3/A31 cells.

Target description

85-100kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Purified

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

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J E Bodwell et al.
The Journal of biological chemistry, 266(12), 7549-7555 (1991-04-25)
Glucocorticoid receptors in vivo are phosphorylated in the absence of hormone and become hyperphosphorylated in the presence of glucocorticoid agonist but not antagonists (Ortí, E., Mendel, D.B., Smith, L.I., and Munck, A. (1989) J. Biol. Chem. 264, 9728-9731). As a
J Richardson et al.
Molecular endocrinology (Baltimore, Md.), 13(4), 546-554 (1999-04-09)
The glutamate synthetase gene (GS) contains a composite glucocorticoid response element (cGRE) comprised of a GRE and an adjacent element with features of both a cAMP-response element (CRE) and a 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE). The CRE/TRE element of

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