03-0205-00

SMC^® Human TDP-43 Immunoassay Kit

kit sufficient for 96 wells

• Sinónimos: TDP-43 Single Molecule Counting kit, TDP-43 immunoassay kit, TDP-43 ultra-sensitive immunoassay, Transactive Response DNA-binding Protein 43 immunoassay kit
• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.77

Propiedades

• Quality Level: 200
• usage: kit sufficient for 96 wells
• species reactivity: human
• packaging: pkg of 1 ea
• manufacturer/tradename: SMC^®
• parameter: 100 μL sample volume (CSF); 12.5 μL sample volume (serum and plasma)
• assay range: intra-assay cv: ≤7%; (n=5); linearity: 80-120%; recovery range: 80-120%; sensitivity: 5.21 pg/mL; standard curve range: 2.6-6,000 pg/mL; inter-assay cv: ≤11%; (n=3)
• technique(s): single molecule counting: suitable
• input: cerebrospinal fluid (CSF); plasma; serum
• shipped in: wet ice
• storage temp.: 2-8°C

Descripción

General description

The human Transactive Response DNA-binding Protein 43 (TDP-43) is a transcriptional repressor which can bind to both DNA and RNA, and regulate functions such as mRNA splicing, microRNA biogenesis, and transcription. While this 414 amino acid long protein can be found in a variety of tissue types, it is most frequently studied in the context of neuroscience research, as misfolding, phosphorylation, and aggregation of TDP-43 in neurons can has been observed in a variety of neurodegenerative disorders, including frontotemporal dementia (FTL), amyotrophic lateral sclerosis (ALS), and certain subsets of Alzheimer’s disease patients. To empower research to evaluate TDP-43 as a cognitive biomarker in both healthy and disease states such as ALS and FTL, the new SMC^® Human TDP-43 High Sensitivity Immunoassay Kit scientists can measure this analyte in CSF, serum, and plasma samples even at low abundance.

Research Category:
Neuroscience
neurological

Research Sub-Category:
Alzheimer′s Disease
Aging
Nervous System
Neurodegenerative Diseases
Neurofilament & Neuron Metabolism
Neuronal & Glial Markers
Neuroregenerative Medicine
Neuroscience

Technique(s)
SMC^® : High sensitivity protein biomarker detection immunoassay

Specificity

This assay was tested for cross-reactivity with phospho-α-synuclein (S129) and phospho-Tau (T181). No cross-reactivity was detected with these analytes.

Application

used for ultrasensitive quantification of Human TDP-43 in human serum, plasma, and CSF.

Features and Benefits

This SMC^® kit features:

• Accurate and reproducible performance on the state-of-the-art SMCxPRO^® ultrasensitive immunoassay system
• Compatibility with automated liquid handling

Legal Information

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H302 + H332,H311,H319,H360FD,H412
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable