P-164

Phosphatidylethanol 16:0/18:1-D₅ (PEth 16:0/18:1-D5) solution

100 μg/mL in methanol ((as free phosphate)), certified reference material, ampule of 1 mL, Cerilliant^®

• Fórmula empírica (notación de Hill): C₃₉H₆₉D₅O₈P · NH₄
• Número de CAS: 1612140-92-7
• Peso molecular: 725.04
• MDL number: MFCD30718210
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: certified reference material
• Quality Level: 300
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol ((as free phosphate))
• format: single component solution
• storage temp.: −70°C

Descripción

General description

This stable-labeled internal standard is suitable for quantitation of PEth 16:0/18:1 in LC/MS or GC/MS applications. PEth 16:0/18:1, also known as phosphatidylethanol 16:0/18:1, is a sensitive and specific biomarker for alcohol use and abuse. Since the detection window of PEth 16:0/18:1 in blood is longer than that of ethyl glucuronide (EtG) or ethyl sulfate (EtS) in urine, measurement of blood PEth 16:0/18:1 level is routinely performed in clinical toxicology and forensic testing applications such as abstinence monitoring and workplace drug testing. PEth 16:0/18:1 has also been investigated as a biomarker to confirm prenatal alcohol exposure (PAE).

Application

• PEth 16:0/18:1-D5 in clinical biomarker research: A study in the Journal of Chromatography B validated a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for analyzing erythrocyte phosphatidylethanol, including deuterated standards like PEth 16:0/18:1-D5. This method highlights critical considerations for using PEth as a clinical biomarker, particularly in monitoring alcohol consumption. The use of deuterated PEth standard ensures precision in quantifying PEth levels, supporting its role in lipidomics and alcohol abuse biomarker detection (White et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes,Central nervous system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 49.5 °F
• flash_point_c: 9.7 °C