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E-016

Supelco

Etil-β-D-glucurónido

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C8H14O7
Número de CAS:
17685-04-0
Peso molecular:
222.19
EC Number:
200-659-6
MDL number:
MFCD09037574
UNSPSC Code:
41116107
PubChem Substance ID:
329798946
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

O[C@H]1[C@H](O)[C@@H](C(O)=O)O[C@@H](OCC)[C@@H]1O

InChI

1S/C8H14O7/c1-2-14-8-5(11)3(9)4(10)6(15-8)7(12)13/h3-6,8-11H,2H2,1H3,(H,12,13)/t3-,4-,5+,6-,8+/m0/s1

InChI key

IWJBVMJWSPZNJH-UQGZVRACSA-N

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Categorías relacionadas

General description

This Certified Reference Material is widely used in forensic analysis and clinical toxicology applications to determine blood alcohol content.

Ethyl-β-D-glucuronide (EtG) is a water-soluble and stable metabolite of ethanol, used as a routine biomarker in alcohol abuse monitoring. A very small fraction of ethanol undergoes degradation to EtG, and it can be detected in body fluids as well as hair.

Application

The certified reference solution (CRM) in solution can also be used as follows:

  • Multi-residue analysis of different alcohol metabolites in human blood plasma and urine samples by ultra-high performance liquid chromatography (UHPLC) combined with tandem mass spectrometry (MS/MS)
  • Optimization of a supercritical fluid chromatography-tandem mass spectrometric (SFC-MS/MS) method for the separation and quantification of highly polar drugs and their metabolites using an ion-exchange stationary phase from human urine samples
  • Evaluation of a paired ion electrospray ionization mass spectrometric (PIESI-MS) approach coupled with high performance liquid chromatographic (HPLC) procedure for the detection and measurement of drug metabolites in urine samples
  • Assess the impact of sample preparation of hair samples on the quantitative analysis of ethyl-β-D-glucuronide by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry
  • Analysis of ethyl-β-D-glucuronide as a urinary biomarker in human urine samples by a benchtop gas chromatograph coupled with a mass spectrometer (GC-MS)

Features and Benefits

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Referencia del producto
Descripción
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Multicomponent Alcohol Calibration Kit (C1-C3) solution, in H2O (varied conc.), ampule of 3 × 1.2 mL, certified reference material, Cerilliant®

B-020

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A-056

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A-057

Multicomponent Alcohol Mix 500, 500 μg/mL each component in H2O, ampule of 1.2 mL, certified reference material, Cerilliant®

A-061

Multicomponent Alcohol Mix-4000, 4000 μg/mL each component in H2O, ampule of 1.2 mL, certified reference material, Cerilliant®

A-076

Multicomponent Alcohol Mix-100, 100 μg/mL each component in H2O, ampule of 1.2 mL, certified reference material, Cerilliant®

E-015

Etil-β-D-glucurónido, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

E-048

Etil-β-D-glucurónido-(etil-d5), 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

E-063

Etil-β-D-glucurónido-(etil-d5), 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

E-064

Ethyl sulfate sodium salt, 1.0 mg/mL in methanol (as ethyl sulfate), ampule of 1 mL, certified reference material, Cerilliant®

E-066

Sulfato de etil-d5 sodium salt, 1.0 mg/mL in methanol (as ethyl sulfate), ampule of 1 mL, certified reference material, Cerilliant®

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sensitive detection of anionic metabolites of drugs by positive ion mode HPLC-PIESI-MS
Guo H, et al.
International Journal of Mass Spectrometry, 389, 14-25 (2015)
A simplified approach for determination of urinary ethyl glucuronide by gas chromatography-mass spectrometry
Ghosh S, et al.
Journal of analytical science and technology, 12, 1-9 (2021)
Jeremy N Matlow et al.
Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharamcologie clinique, 19(3), e473-e482 (2012-11-06)
Ethyl glucuronide (EtG) is arising as a promising biomarker of heavy prenatal alcohol exposure, however its transfer across the human placenta is still unclear and is currently being investigated using the ex vivo placental perfusion model. This model allows for
J N Matlow et al.
Placenta, 34(4), 369-373 (2013-02-05)
Alcohol consumption during pregnancy can lead to Fetal Alcohol Spectrum Disorder (FASD), and because maternal self-reports are often unreliable, biomarkers of alcohol use are sometimes necessary to accurately determine fetal risk. Ethyl glucuronide (EtG), a direct metabolite of ethanol, has
Scott H Stewart et al.
Alcohol and alcoholism (Oxford, Oxfordshire), 48(1), 83-87 (2012-09-28)
Hair ethyl glucuronide (EtG) is a promising biomarker of moderate-to-heavy alcohol consumption and may have utility in detecting and monitoring alcohol use in clinical populations where alcohol use is of particular importance. This study evaluated the relationship between hair EtG
Ver todos los artículos relacionados

Artículos

Extended Lifetime Ethanol Metabolites and Method Development for Ethyl Sulfate and Ethyl Glucuronide Separation

Review of clinically relevant ethanol metabolites and analytical method development for the analysis of ethyl glucuronide and ethyl sulfate in urine matrix.

Determination of Ethyl Glucuronide and Ethyl Sulfate in Urine using LC-MS/MS

This study is aimed at developing and validating an LC-ESI-ion trap-MS/MS method for identification and quantification of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as ethanol biomarkers for urine analysis.

LC/MS Analysis of Ethanol Metabolites in Urine on Ascentis® Express OH5 after Dilution with Deuterated Internal Standards

The method shown uses HILIC mode on an Ascentis® Express OH5 column to retain both analytes well, making it very likely to be more robust and reliable, as well as highly MS-friendly.

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