860506P

C6 Ceramide (d18:1/6:0)

Avanti Research^™ - A Croda Brand

• Sinónimos: N-hexanoyl-D-erythro-sphingosine
• Fórmula empírica (notación de Hill): C₂₄H₄₇NO₃
• Número de CAS: 124753-97-5
• Peso molecular: 397.63
• UNSPSC Code: 12352211
• NACRES: NA.25

Propiedades

• form: powder
• packaging: pkg of 1 × 10 mg (860506P-10mg); pkg of 1 × 5 mg (860506P-5mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand
• lipid type: sphingolipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+
• InChI key: NPRJSFWNFTXXQC-VHEBQXMUSA-N

Descripción

General description

C6 Ceramide (d18:1/6:0) is a short chain and a cell permeable ceramide. It comprises amino alcoholic chain attached to fatty acyl chain via an amide linkage.

Application

C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.

Biochem/physiol Actions

C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis. When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines. C6 Ceramide may serve as an adjunct in chemotherapy. It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation.

Packaging

5 mL Amber Glass Screw Cap Vial (860506P-10mg)

5 mL Amber Glass Screw Cap Vial (860506P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable