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Key Documents

790625P

Avanti

DC-Chol/DOPE Blend

Avanti Research™ - A Croda Brand 790625P, powder

Sinónimos:

DC-Chol/DOPE Blend, DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w)

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About This Item

UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 25 mg (790625P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 790625P

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

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General description

DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (DOPE) lipid complex comprises the cationic lipid DC-Cholesterol and the neutral helper lipid DOPE.

Application

DC-Chol/DOPE Blend has been used:
  • in the preparation of liposomes for ferritin heavy chain 1 (FTH1) siRNA (small interference RNA) transfection studies
  • to compare its cytotoxicity tests with ginger derived nanoparticles in colon-26 cells
  • as a standard control in MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to evaluate biocompatibility of ginger derived lipid vesicles

Biochem/physiol Actions

DC-Cholesterol/Dioleoyl Phosphatidylethanolamine (30:70, w/w) helps in transfection of therapeutic small interference RNA (siRNA). DC-Chol/DOPE liposomes are cationic, unilamellar and spherical in nature. It aids in improved condensation of DNA for transfection studies.

Packaging

5 mL Clear Glass Sealed Ampule (790625P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Meike-Kristin Abraham et al.
Nanotheranostics, 1(2), 154-165 (2017-10-27)
Rationale: Genetic therapy using modified mRNA for specific therapeutic protein expression for disease treatment and vaccination represents a new field of therapeutic and diagnostic medicine. Non-viral vectors transfection using biocompatible nanoliposomes enables safe and efficient delivery of therapeutic mRNA. Objective:
Alberto Rodríguez-Pulido et al.
The journal of physical chemistry. B, 112(39), 12555-12565 (2008-08-30)
A 1:1 mixture of the cationic lipid 3beta-[ N-( N', N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol) and the zwitterionic lipid, 1,2-dioleoyl- sn-glycero-3-phosphoetanolamine (DOPE), has been used to compact calf-thymus DNA (CT-DNA) in aqueous buffered solution at 298.15 K. The formation process of this

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