141101P
Avanti
Brain Extract Polar
Avanti Research™ - A Croda Brand
Sinónimos:
Brain Polar Lipid Extract (Porcine)
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About This Item
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form
powder
packaging
pkg of 1 × 100 mg (141101P-100mg)
pkg of 5 × 100 mg (141101P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
lipid extracts
shipped in
dry ice
storage temp.
−20°C
Categorías relacionadas
General description
Brain Extract Polar comprises phosphatidylethanolamine as a major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.
Application
Brain Extract Polar has been used in parallel artificial membrane permeability assay (PAMPA) for coating membrane to evaluate blood brain-barrier permeability, and for drug permeability studies.
Biochem/physiol Actions
Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes. Brain lipid, especially the polar fraction play a key role in the inhibition of prion seeded amyloid formation.
Packaging
5 mL Clear Glass Sealed Ampule (141101P-100mg)
5 mL Clear Glass Sealed Ampule (141101P-500mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs
Hallifax D, et al.
European Journal of Pharmaceutical Sciences, 45(5), 570-574 (2012)
Rapid screening of brain-penetrable antioxidants from natural products by blood-brain barrier specific permeability assay combined with DPPH recognition
Zhu J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 151, 42-48 (2018)
Estefanía de Munck et al.
PloS one, 11(9), e0162723-e0162723 (2016-09-16)
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal
David S Wexler et al.
Journal of biomolecular screening, 10(4), 383-390 (2005-06-21)
Solubility and permeability are intimately linked in drug absorption processes. They have, however, been traditionally assayed separately. To support this linkage, a combined solubility/permeability assay was developed for determining absorption properties of chemical entities. First, solubility is determined at 4
Endogenous brain lipids inhibit prion amyloid formation in vitro
Hoover CE, et al.
Journal of Virology, 91(9), e02162-e02116 (2017)
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