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P1781

Sigma-Aldrich

Pteroic acid

≥93%

Sinónimos:

4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid

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About This Item

Fórmula empírica (notación de Hill):
C14H12N6O3
Número de CAS:
119-24-4
Peso molecular:
312.28
MDL number:
MFCD00075823
UNSPSC Code:
12352100
PubChem Substance ID:
57654505
NACRES:
NA.22

Quality Level

200

assay

≥93%

form

powder

SMILES string

NC1=NC(=O)C2=NC(CNc3ccc(cc3)C(O)=O)=CNC2=N1

InChI

1S/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)

InChI key

JOAQINSXLLMRCV-UHFFFAOYSA-N

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Application

Pteroic acid can be used as a starting material to synthesize labeled folate binding protein (FBP) ligands, which are used in many homogeneous chemiluminescent assay formats for the detection of folic acid.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
BCCH0300
BCCF1193
BCCC3033
BCBZ5374
BCBV9816

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R L Stephens et al.
The Journal of pharmacology and experimental therapeutics, 239(3), 627-633 (1986-12-01)
Folic acid (FA) and 5-formyltetrahydrofolic acid (FTHF) have been shown previously to produce a marked stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens. This study was designed to determine whether the hypermotility response produced by the
M J Akhtar et al.
Journal of pharmaceutical and biomedical analysis, 16(1), 95-99 (1998-02-03)
A high performance liquid chromatographic procedure was developed to determine folic acid and its photodegradation products, p-aminobenzoic acid, pterine-6-carboxylic acid, p-aminobenzoyl-L-glutamic acid, and pteroic acid in the presence of riboflavin. The method involves reversed phase, paired-ion chromatography on mu-BondaPak C18
H Oe et al.
Journal of nutritional science and vitaminology, 29(5), 523-531 (1983-10-01)
A sensitive radioassay method has been developed to quantitate the activity of the folate-hydrolyzing enzyme which catalyzes the hydrolysis of folic acid to pteroic acid and glutamic acid. The method is based on analyzing [2-14C]pteroic acid separated by a thin-layer
Kerim Babaoglu et al.
Structure (London, England : 1993), 12(9), 1705-1717 (2004-09-03)
Dihydropterate synthase (DHPS) is the target for the sulfonamide class of antibiotics, but increasing resistance has encouraged the development of new therapeutic agents against this enzyme. One approach is to identify molecules that occupy the pterin binding pocket which is
H S Tillinghast et al.
Journal of cell science, 87 ( Pt 1), 45-53 (1987-02-01)
Following a previous study indicating a sensitivity to folate during the developmental phase of Dictyostelium discoideum, a series of pteridines were investigated for their ability to induce amoebal chemotaxis during development of this organism. Several compounds were found to resemble
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