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H0751

Sigma-Aldrich

Homogentisic acid

crystalline

Sinónimos:

2,5-Dihydroxyphenylacetic acid

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About This Item

Fórmula lineal:
(HO)2C6H3CH2CO2H
Número de CAS:
451-13-8
Peso molecular:
168.15
Beilstein/REAXYS Number:
2692860
EC Number:
207-192-7
MDL number:
MFCD00004324
UNSPSC Code:
12352100
PubChem Substance ID:
57654223
NACRES:
NA.22

form

crystalline

Quality Level

200

color

off-white to tan

mp

150-152 °C (lit.)

storage temp.

2-8°C

SMILES string

OC(=O)Cc1cc(O)ccc1O

InChI

1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)

InChI key

IGMNYECMUMZDDF-UHFFFAOYSA-N

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General description

Homogentisic acid (HGA) is an intermediate formed during the catabolism of phenylalanine and tyrosine. Alkaptonuria, a metabolic disorder, is characterized by high levels of HGA in serum and urine due to the deficiency of the enzyme homogentisic acid oxidase, which is involved in the degradation of HGA.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
BCCG5987
BCCC3256
BCBW0119
BCBX0399
BCBT5697

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Ácido gálico 97.5-102.5% (titration)

Sigma-Aldrich

G7384

Ácido gálico

Chanika Phornphutkul et al.
The New England journal of medicine, 347(26), 2111-2121 (2002-12-27)
Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There is no effective therapy for this disorder, although nitisinone inhibits the
A M Taylor et al.
Arthritis and rheumatism, 63(12), 3887-3896 (2011-12-01)
Alkaptonuria is a genetic disorder of tyrosine metabolism, resulting in elevated circulating concentrations of homogentisic acid. Homogentisic acid is deposited as a polymer, termed ochronotic pigment, in collagenous tissues, especially cartilages of weight-bearing joints, leading to a severe osteoarthropathy. We
Yaping Wang et al.
BMC microbiology, 17(1), 122-122 (2017-05-27)
Combining experimental and computational screening methods has been of keen interest in drug discovery. In the present study, we developed an efficient screening method that has been used to screen 2100 small-molecule compounds for alanine racemase Alr-2 inhibitors. We identified
Pediatric Dermatology E-Book, 507-507 (2011)
C Bory et al.
Clinica chimica acta; international journal of clinical chemistry, 189(1), 7-11 (1990-07-01)
The clinical and biochemical features of five cases of alcaptonuria were reported. The concentration of homogentisic acid was determined in urine and also in plasma using a rapid, sensitive and specific HPLC method. In all five cases, the concentrations of
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