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Key Documents

933082

Sigma-Aldrich

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit

for CIJ synthesis of nanoparticles

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.21

Application

NanoFabTx™ NanoFlash PEG-PLA drug formulation screening kit is a ready to use nanoformulation kit for flash nanoprecipitation synthesis of PEGylated PLA nanoparticles for drug delivery research applications. This kit contains rationally selected PEGylated PLA polymers and stabilizer, enabling users to screen and select nanoformulations without the need for lenghty trial and error optimization. These PEGylated PLA polymers have been widely used in drug delivery systems for controlled drug release of many different types of therapeutic molecules.

This kit has been curated and designed for flash nanoprecipitiaton (FNP) nanoparticle synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.

Features and Benefits

  • Ready-to-use nanoformulation kit for PEGylated nanoparticles
  • Step-by-step flash nanoprecipitation protocol
  • Create specifically sized, biodegradable, PEGylated PLA nanoparticles
  • Maximize the encapsulation of hydrophobic drugs
  • Two different PEGylated PLAs are included
  • Optimized for 60 nm-150 nm nanoparticles
A flash nanoprecipitation protocol to prepare drug-encapsulated nanoparticles using the NanoFabTx™ NanoFlash CIJ Mixer is included and can be found under the Protocol section of this page.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Jing Han et al.
Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
Nazila Kamaly et al.
Chemical Society reviews, 41(7), 2971-3010 (2012-03-06)
Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery
Byung Kook Lee et al.
Advanced drug delivery reviews, 107, 176-191 (2016-06-06)
Poly(d,l-lactic acid) (PLA) has been widely used for various biomedical applications for its biodegradable, biocompatible, and nontoxic properties. Various methods, such as emulsion, salting out, and precipitation, have been used to make better PLA micro- and nano-particle formulations. They are

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