914487

2-(Diphenylphosphanyl)benzamide

≥95%

• Sinónimos: 2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction
• Fórmula empírica (notación de Hill): C₁₉H₁₆NOP
• Número de CAS: 343254-74-0
• Peso molecular: 305.31
• MDL number: MFCD32851675
• UNSPSC Code: 12352200
• NACRES: NA.22

Propiedades

• Quality Level: 100
• assay: ≥95%
• form: powder
• storage temp.: −20°C
• SMILES string: P(c3c(cccc3)C(=O)N)(c2ccccc2)c1ccccc1
• InChI: 1S/C19H16NOP/c20-19(21)17-13-7-8-14-18(17)22(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H,(H2,20,21)
• InChI key: IHGZKYLRNBICEF-UHFFFAOYSA-N

Descripción

General description

It is recommended to make fresh stock stolutions prior to each use.

Application

2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N₃ (cat# 913812).

Other Notes

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Small-molecule control of protein function through Staudinger reduction

A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3