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911496

Sigma-Aldrich

Polyester bis-MPA dendron, 4 carboxyl, 1 Rhodamine (core)

generation 2

Sinónimos:

Bis-MPA dendron, Fluorescent linker, Fluoresent dendron

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About This Item

Fórmula empírica (notación de Hill):
C67H87ClN2O28
Peso molecular:
1403.86
UNSPSC Code:
12162002
NACRES:
NA.23

form

solid

mol wt

generation 2

no. Surface Groups

4

color

red to pink

functional group

(Rhodamine(core))

storage temp.

−20°C

Categorías relacionadas

General description

  • Polymer architecture: Dendron
  • End Group Functionality: Carboxyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid

Application

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The corona of this product is functionalized by carboxyl groups, which can be readily used in bioconjugation. The rhodamine labeled core allows its application in bioimaging.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Artículos

The Potential of Dendritic Polyester Scaffolds as Biocompatible Drug Delivery Agents

Professor Michael Malkoch provides an overview of the unique properties of dendritic molecules and their application in biomedical fields. He highlights bis-MPA dendritic scaffolds as a promising biodegradable and biocompatible platform for drug delivery applications

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

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