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Key Documents

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900671

Sigma-Aldrich

Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)

5k-2k

Sinónimos:

mPEG-b-PCL, mPEG-PCL

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About This Item

Fórmula lineal:
CH3O(CH2CH2O)n(COCH2CH2CH2CH2CH2O)mH
UNSPSC Code:
12352200
NACRES:
NA.23

Quality Level

100

form

powder

mol wt

PCL average Mn ~2,000
PEG average Mn ~5,000

transition temp

flash point >230 °F
Tm 54-57 °C

storage temp.

2-8°C

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Application

Biocompatible, amphiphilic block copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These materials have been used as a block copolymer surfactant as well as in control release and nanoparticle formulation for drug delivery applications. Well-defined materials with varying properties can be prepared by controlling the relative length of each polymer block. Hydroxyl termination allows for facile further chemical modification of these materials.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

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Simple solvothermalsynthesis of hydrophobic magnetic monodispersed Fe3O4 nanoparticles.
Liu J, et al.
Mat. Res. Bul., 48(2), 416-421 (2013)
On the mechanism of formation of vesicles from poly(ethylene oxide)-block-poly(caprolactone) copolymers.
Adams DJ, et al.
Soft Matter, 5, 3086-3096 (2009)
Xu Wen Ng et al.
Journal of pharmaceutical sciences, 103(11), 3631-3640 (2014-09-17)
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Timolol maleate (TM) has been used for many years for the reduction of intraocular pressure (IOP) in glaucoma patients. However, the topical mode of administration (eyedrops) is far from optimal because of the issues of low bioavailability, high drug wastage
Bhuvana S Doddapaneni et al.
Journal of controlled release : official journal of the Controlled Release Society, 220(Pt A), 503-514 (2015-11-19)
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Polymersomes for Drug Delivery

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