74540

Nordihydroguaiaretic acid

≥97.0% (HPLC)

• Sinónimos: Masoprocol
• Fórmula lineal: [-CH(CH₃)CH₂C₆H₃-1,2-(OH)₂]₂
• Número de CAS: 500-38-9
• Peso molecular: 302.36
• Beilstein/REAXYS Number: 2056826
• EC Number: 207-903-0
• MDL number: MFCD00002206
• UNSPSC Code: 12352100
• PubChem Substance ID: 57652455
• NACRES: NA.22

Propiedades

• Quality Level: 100
• assay: ≥97.0% (HPLC)
• form: crystals
• impurities: ≤2% water
• mp: 184-186 °C (lit.)
• SMILES string: CC(Cc1ccc(O)c(O)c1)C(C)Cc2ccc(O)c(O)c2
• InChI: 1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
• InChI key: HCZKYJDFEPMADG-UHFFFAOYSA-N
• Gene Information: mouse ... Alox12(11684)

Descripción

General description

Nordihydroguaiaretic acid (NDGA) is used as an antioxidant and potent scavenger of reactive oxygen species (ROS).

Application

Nordihydroguaiaretic acid can be used:

• In the synthesis of nordihydroguaiaretic acid derivatives with potent HIV inhibition activity.
• As a starting material in the synthesis of tetra-O-methylnordihydroguaiaretic acid.

Biochem/physiol Actions

Lipoxygenase inhibitor; polyphenol-bearing o-dihydroxy (catechol) structure.

Other Notes

Inhibitor of broad bean lipoxygenase

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H335
• pcodes: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves