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Mass spectrometry-based urinary metabolomics for the investigation on the mechanism of action of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves against ischemic stroke in rats.

Rongjin Wang et al.

Journal of ethnopharmacology, 241, 111969-111969 (2019-05-28)

As a traditional Chinese medicine, Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves (ESL) can treat ischemic, neurasthenia, and hypertension diseases. However, only few studies have been conducted on the mechanism of action of ESL for ischemic disease treatment. This study

Integrated pathological cell fishing and network pharmacology approach to investigate main active components of Er-Xian decotion for treating osteoporosis.

Nani Wang et al.

Journal of ethnopharmacology, 241, 111977-111977 (2019-05-29)

Oxidative damage to osteoblasts was a key factor in the development of osteoporosis. Er-Xian Decotion (EXD) is widely used in China for the treatment of osteoporosis, which has a variety of antioxidant active ingredients. EXD may be an important source

Hepcidin Deficiency Protects Against Atherosclerosis.

Rajeev Malhotra et al.

Arteriosclerosis, thrombosis, and vascular biology, 39(2), 178-187 (2018-12-28)

Objective- Inflammatory stimuli enhance the progression of atherosclerotic disease. Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron levels and traps iron within macrophages. The role of macrophage

Differential Protein Expression Profiles of Bronchoalveolar Lavage Fluid Following Lipopolysaccharide-Induced Direct and Indirect Lung Injury in Mice.

Xinping Yue et al.

International journal of molecular sciences, 20(14) (2019-08-03)

The pathogenic mechanisms of acute lung injury due to direct and indirect pulmonary insults are incompletely understood. Using an unbiased, discovery and quantitative proteomic approach, we examined bronchoalveolar lavage fluid (BALF) proteome following lipopolysaccharide (LPS)-induced direct and indirect lung injury

Analysis for microbial denitrification and antibiotic resistance during anaerobic digestion of cattle manure containing antibiotic.

Kaiyu Zhang et al.

Bioresource technology, 291, 121803-121803 (2019-07-22)

This study investigated the effects of tylosin (0, 10, and 100 mg/kg dry weight) on the denitrification genes and microbial community during the anaerobic digestion of cattle manure. N2 emissions were reduced and N2O emissions were increased by 10 mg/kg tylosin. Adding

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