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244309

Ethyl β-carboline-3-carboxylate

Name: Ethyl β-carboline-3-carboxylate
Brand: ALDRICH

97%

Sinónimos:

β-CCE, Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

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About This Item

Fórmula empírica (notación de Hill):

C₁₄H₁₂N₂O₂

Número de CAS:

74214-62-3

Peso molecular:

240.26

MDL number:

MFCD00009730

UNSPSC Code:

12352100

PubChem Substance ID:

24854665

NACRES:

NA.22

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Sigma-Aldrich

E006

β-Carboline-3-carboxylic acid N-methylamide

assay

97%

form

solid

mp

228-230 °C (lit.)

functional group

ester

SMILES string

CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

InChI key

KOVRZNUMIKACTB-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA5(2558) , GABRG2(2566)
rat ... Gabra2(29706)

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Contrasting effects of ethyl beta-carboline-3-carboxylate (beta CCE) and diazepam on cerebellar cyclic GMP content and antagonism of both effects by Ro 15-1788, a specific benzodiazepine receptor blocker.

B K Koe et al.

European journal of pharmacology, 90(1), 97-102 (1983-05-20)

Ethyl beta-carboline-3-carboxylate (beta CCE), a benzodiazepine antagonist, was found to increase basal levels of cyclic GMP in rat cerebellum. beta CCE also augmented the elevation of cyclic GMP concentrations induced by isoniazid, in contrast to diazepam which blocked this effect

Relaxant effects of beta-carbolines on rat aortic rings.

B Elgoyhen et al.

The Journal of pharmacology and experimental therapeutics, 261(2), 534-539 (1992-05-01)

The effects of two beta-carbolines, methyl 6,7-dimethoxy-4-ethyl-beta- carboline-3-carboxylate (DMCM) and ethyl beta-carboline-3-carboxylate (beta CCE) were assayed on rat aortic rings precontracted with different agonists. The beta-carbolines tested induced a concentration-dependent (2-200 microM) relaxation of aortic rings precontracted with 30 mM

Down-regulation of benzodiazepine receptors by ethyl beta-carboline-3-carboxylate in cerebrocortical neurons.

M Katsura et al.

European journal of pharmacology, 298(1), 71-77 (1996-02-29)

Effect of exposure of primary cultured cerebral cortical neurons to ethyl beta-carboline-3-carboxylate (beta-CCE) on the function of benzodiazepine receptors was studied. Exposure of neurons to beta-CCE (0.1-10 microM) decreased the binding of [3H]flunitrazepam to extensively washed membrane fractions in a

Combination of buspirone and other drugs with beta-CCE in monkeys: effects on respiration and behavior.

J G Wettstein et al.

Pharmacology, biochemistry, and behavior, 44(3), 633-641 (1993-03-01)

The respiratory and behavioral effects of the benzodiazepine receptor (BZR) inverse agonist ethyl-beta-carboline-3-carboxylate (beta-CCE) were determined alone and in combination with buspirone, lorazepam, flumazenil, and SR 95195 in rhesus monkeys. For the respiratory studies, one group of monkeys inhaled either

Benzodiazepines induce a conformational change in the region of the gamma-aminobutyric acid type A receptor alpha(1)-subunit M3 membrane-spanning segment.

D B Williams et al.

Molecular pharmacology, 58(5), 1129-1136 (2000-10-20)

Benzodiazepine binding to gamma-aminobutyric acid type A (GABA(A)) receptors allosterically modulates GABA binding and increases the currents induced by submaximal GABA concentrations. Benzodiazepines induce conformational changes in the GABA-binding site in the extracellular domain, but it is uncertain whether these

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