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129445

Sigma-Aldrich

Indole-3-carboxaldehyde

97%

Sinónimos:

β-Indolylaldehyde, 3-Formylindole, 3-Indolylformaldehyde, Indole-3-carbaldehyde, NSC 10118

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About This Item

Fórmula empírica (notación de Hill):
C9H7NO
Número de CAS:
487-89-8
Peso molecular:
145.16
Beilstein/REAXYS Number:
114117
EC Number:
207-665-8
MDL number:
MFCD00005622
UNSPSC Code:
12352100
PubChem Substance ID:
24847903
NACRES:
NA.22

assay

97%

form

solid

mp

193-198 °C (lit.)

SMILES string

O=Cc1c[nH]c2ccccc12

InChI

1S/C9H7NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-6,10H

InChI key

OLNJUISKUQQNIM-UHFFFAOYSA-N

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General description

Indole-3-carboxaldehyde can undergo Schiff bases condensation to form multifunctional silica nano-vehicles and magnetic nanoparticles.

Application

Indole-3-carboxaldehyde was used to prepare analogs of the indole phytoalexin cyclobrassinin with NR1R2 group. It was also used as the starting material for the synthesis of higher order indoles including isoindolo[2,1-a]indoles, aplysinopsins, and 4-substituted-tetrahydrobenz[cd]indoles.
Reactant for preparation of:
  • Analgesic agents
  • Hypoglycemic agents
  • Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
  • Antibacterial and antifungal agents
  • Antiamoebic and cytotoxic agents
  • Inhibitors of the Dengue virus protease with antiviral activity in cell-culture
  • Curcumin analogues as possible anti-proliferative & anti-inflammatory agents
  • Inhibitors of Bcl-2 family proteins
  • Inhibitors of the C-terminal domain of RNA Polymerase II as antitumor agents
  • Inhibitors of TNF-α and IL-6 with anti-tubercular activity

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Qiu-Yun Chen et al.
Colloids and surfaces. B, Biointerfaces, 114, 158-163 (2013-11-05)
Multifunctional silica nano-vehicles (SiO2@indol-IL) and magnetic nanoparticles (Fe3O4@indol-IL) were constructed through the Schiff bases condensation of indole-3-carboxaldehyde and 4-acetyl-N-allyl pyridinium chloride (ILs) with the amine groups of silica and magnetic nanoparticles. SiO2@indol-IL can inhibit the proliferation of HepG-2 cells in
Synthetic Communications, 23, 55-55 (1993)
Heterocycles, 38, 1479-1479 (1994)
Mariana Budovská et al.
Bioorganic & medicinal chemistry, 21(21), 6623-6633 (2013-09-10)
An effective synthesis of analogs of the indole phytoalexin cyclobrassinin with NR1R2 group instead of SCH3 was developed starting from indole-3-carboxaldehyde. The target compounds were prepared by spirocyclization of 1-Boc-thioureas with the formation of isolable spiroindoline intermediates, followed by the
Indian J. Chem. B, 33, 4-4 (1994)
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