跳轉至內容
Merck
  • Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis.

Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis.

Nature communications (2020-10-22)
Bénédicte Oulès, Christina Philippeos, Joe Segal, Matthieu Tihy, Matteo Vietri Rudan, Ana-Maria Cujba, Philippe A Grange, Sven Quist, Ken Natsuga, Lydia Deschamps, Nicolas Dupin, Giacomo Donati, Fiona M Watt
摘要

Although acne is the most common human inflammatory skin disease, its pathogenic mechanisms remain incompletely understood. Here we show that GATA6, which is expressed in the upper pilosebaceous unit of normal human skin, is down-regulated in acne. GATA6 controls keratinocyte proliferation and differentiation to prevent hyperkeratinisation of the infundibulum, which is the primary pathological event in acne. When overexpressed in immortalised human sebocytes, GATA6 triggers a junctional zone and sebaceous differentiation program whilst limiting lipid production and cell proliferation. It modulates the immunological repertoire of sebocytes, notably by upregulating PD-L1 and IL10. GATA6 expression contributes to the therapeutic effect of retinoic acid, the main treatment for acne. In a human sebaceous organoid model GATA6-mediated down-regulation of the infundibular differentiation program is mediated by induction of TGFβ signalling. We conclude that GATA6 is involved in regulation of the upper pilosebaceous unit and may be an actionable target in the treatment of acne.

材料
產品編號
品牌
產品描述

Sigma-Aldrich
视黄酸, ≥98% (HPLC), powder
庫存單位
包裝尺寸
供貨能力
價格
數量
Sigma-Aldrich
Triton X-100, laboratory grade
庫存單位
包裝尺寸
供貨能力
價格
數量
Sigma-Aldrich
Troglitazone, ≥98% (HPLC)
庫存單位
包裝尺寸
供貨能力
價格
數量
Sigma-Aldrich
Anti-Plet-1 (Placenta-expressed transcript 1 protein) Antibody, clone 1D4, clone 1D4, from rat
庫存單位
包裝尺寸
供貨能力
價格
數量