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Key Documents

59357-U40

Supelco

Discovery® Cyano (5 µm) HPLC Columns

L × I.D. 25 cm × 4 mm, HPLC Column

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About This Item

分類程式碼代碼:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Cyano HPLC 色谱柱 ®, 5 μm particle size, L × I.D. 25 cm × 4 mm

材料

stainless steel column

agency

suitable for USP L10

產品線

Discovery®

特點

endcapped

製造商/商標名

Discovery®

包裝

1 ea of

標籤範圍

4.5% Carbon loading

參數

≤70 °C temp. range
400 bar pressure (5801 psi)

技術

HPLC: suitable
LC/MS: suitable

長度 × 內徑

25 cm × 4 mm

表面積

200 m2/g

表面覆盖率

3.5 μmol/m2

雜質

<10 ppm metals

基質

silica gel, high purity, spherical base material
fully porous particle

基質活性組

cyano phase

粒徑

5 μm

孔徑

180 Å

工作pH值範圍

2-8

應用

food and beverages

分離技術

hydrophilic interaction (HILIC)
normal phase
reversed phase

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特點和優勢

  • 低疏水性可实现对疏水性化合物的快速洗脱
  • 分析强碱性化合物具有优良的峰形和保留性能
  • 对极性化合物具有较强的保留能力
  • 独特的选择性
  • 保留时间显著小于 C18 柱(通常流动相中所需有机相比例更低)
  • 稳定性好、低流失,适用于 LC-MS 分析
  • 与高含水量的流动相兼容

法律資訊

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

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分析證明 (COA)

Lot/Batch Number

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E F Nemeth et al.
The Journal of pharmacology and experimental therapeutics, 299(1), 323-331 (2001-09-19)
Despite the discovery of many ions and molecules that activate the Ca2+ receptor, there are no known ligands that block this receptor. Reported here are the pharmacodynamic properties of a small molecule, NPS 2143, which acts as an antagonist at
S L Able et al.
British journal of pharmacology, 162(2), 405-414 (2010-09-16)
The P2X7 receptor is implicated in inflammation and pain and is therefore a potential target for therapeutic intervention. Here, the development of a native tissue radioligand binding, localization and ex vivo occupancy assay for centrally penetrant P2X7 receptor antagonists is
Thomas J Woltering et al.
Bioorganic & medicinal chemistry letters, 18(3), 1091-1095 (2007-12-22)
A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of a cyano group by a five-membered heterocycle produced compounds inhibiting the binding of [(3)H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both
Fan Zhang et al.
European journal of medicinal chemistry, 46(7), 3149-3157 (2011-04-26)
A series of novel 2-amino-3-cyano-6-(1H-indol-3-yl)-4-phenylpyridine derivatives were synthesized and their cytotoxic activity against A549, H460, HT-29 and SMMC-7721 cell lines was evaluated in vitro. Among them, ten compounds (10, 11, 14, 16, 17, 26, 27, 29, 30 and 31) displayed
Graciela B Arhancet et al.
Journal of medicinal chemistry, 53(16), 5970-5978 (2010-08-03)
A new 1,4-dihydropyridine 5a, containing a cyano group at the C3 position, was recently reported to possess excellent mineralocorticoid receptor (MR) antagonist in vitro potency and no calcium channel-blocker (CCB) activity. In the present study, we report the structure-activity relationships

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