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About This Item
經驗公式（希爾表示法）:
C9H14N2O5
CAS號碼:
分子量：:
230.22
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.77
推薦產品
形狀
powder
品質等級
顏色
white to light brown
溶解度
DMSO: 2 mg/mL, clear (warmed)
儲存溫度
2-8°C
SMILES 字串
CC(=O)c1nc(c[nH]1)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
1S/C9H14N2O5/c1-4(13)9-10-2-5(11-9)7(15)8(16)6(14)3-12/h2,6-8,12,14-16H,3H2,1H3,(H,10,11)/t6-,7-,8-/m1/s1
InChI 密鑰
CQSIXFHVGKMLGQ-BWZBUEFSSA-N
生化／生理作用
THI 是鞘氨醇-1-磷酸裂解酶的抑制剂，起到免疫抑制剂的作用。鞘氨醇-1-磷酸 (S1P) 裂解酶催化 S1P 不可逆地分解为十六醛和磷酸乙醇胺。减少 S1P 裂解酶活性导致免疫抑制的治疗水平，而没有合成的 S1P 受体激动剂导致的非淋巴病变。
已知 2-乙酰基-4-四羟基丁基咪唑 (THI) 可诱导大鼠外周血淋巴细胞减少。大鼠研究也有报道 THI 可影响淋巴细胞迁移和降解 。
準備報告
THI 可溶于 DMSO，浓度大于 5 mg/mL。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
G F Houben et al.
Toxicology and applied pharmacology, 113(1), 43-54 (1992-03-01)
Administration of ammonia caramel color (AC) to rats may decrease blood lymphocyte counts, specifically in rats fed a diet low in vitamin B6. This effect is associated with 2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI). To characterize and compare the effects of AC and THI
Jaap P P Saers et al.
Journal of human evolution, 135, 102654-102654 (2019-08-30)
The human foot is highly derived relative to that of other hominoids and therefore a topic of intense research in paleoanthropology. While trabecular bone is thought to be highly plastic in response to habitual behavior, knowledge of how trabecular structure
K V Nordlund et al.
Journal of dairy science, 102(7), 6495-6507 (2019-04-30)
Heat load is a challenge for high-producing dairy cows, with adverse consequences on production, reproduction, and welfare. The objectives of this observational study in 2 commercial dairy herds were to determine the effects of environmental heat stress on standing and
V E Reeve et al.
International archives of allergy and immunology, 102(1), 101-106 (1993-01-01)
The compound 2-acetyl-4-tetrahydroxybutylimidazole (THI), a component of ammonia caramel, has been shown to cause lymphopenia and to impair several immune functions in rats and mice. In this study we show that THI effectively suppresses contact hypersensitivity dose responsively in the
S J Gobin et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 27(10), 627-630 (1989-10-01)
The ability of B6 vitamers to prevent the lymphopenic effects of ammonia caramel fed to rats has been evaluated. Diets containing 10 ppm pyridoxine or pyridoxal prevented the lymphopenia produced in rats consuming an 8% (w/v) solution of ammonia caramel
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