T5576

TMPH hydrochloride

solid, (Product is pure based on CHN, NMR and MS results)

• 同義詞: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate hydrochloride
• 經驗公式（希爾表示法）: C₁₆H₃₂ClNO₂
• CAS號碼: 849461-91-2
• 分子量：: 305.88
• MDL號碼: MFCD08277030
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724633
• NACRES: NA.77

屬性

• 品質等級: 100
• 形狀: solid
• 儲存條件: under inert gas
• 顏色: white
• 溶解度: H₂O: 22 mg/mL at ~60 °C
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.CCCCCCC(=O)OC1CC(C)(C)NC(C)(C)C1
• InChI: 1S/C16H31NO2.ClH/c1-6-7-8-9-10-14(18)19-13-11-15(2,3)17-16(4,5)12-13;/h13,17H,6-12H2,1-5H3;1H
• InChI 密鑰: XIDDVJIJIFWGIX-UHFFFAOYSA-N

描述

應用

Studies using TMPH have reported that it can alleviate the seizure-causing effect of levamisole. Additionally, it has been reported that TMPH does not induce behavioral changes in mice¹.

生化／生理作用

2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.

特點和優勢

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

TMPH hydrochloride is soluble in water at 22 mg/ml (at approx. 60° C).

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H317,H319,H335
• 防範說明: P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves