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About This Item
經驗公式（希爾表示法）:
C6HN3Br4
CAS號碼:
分子量：:
434.71
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: 28 mg/mL
儲存溫度
2-8°C
SMILES 字串
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
InChI 密鑰
OMZYUVOATZSGJY-UHFFFAOYSA-N
應用
TBB 用于研究 DNA 损伤介质蛋白 MDC1 的酪蛋白激酶 2 依赖性磷酸化。
生化／生理作用
TBB 与酪蛋白激酶-2 的 Val66 残基结合，抑制 ATP/GTP 的结合。TBB 具有细胞渗透性；在 Jurkat 细胞中诱导半胱天冬酶依赖性细胞凋亡并降解造血谱系细胞特异性蛋白 1。
TBB 是酪蛋白激酶-2 (CK2) 的高度选择性 ATP/GTP 竞争性抑制剂（IC 50 = 900 nM 和 1.6 mM，分别使用大鼠肝脏和重组人 CK2）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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