SRP8054

Tim-1 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 同義詞: Hepatitis A virus cellular receptor 1, KIM1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin and mucin domain-containing protein 4, TIMD1
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 生物源: human
• 重組細胞: expressed in CHO cells
• 化驗: ≥98% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: monomer 57 kDa by calculation
• 包裝: pkg of 100 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 雜質: <0.06 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: Q96D42
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... HAVCR1(26762)

描述

一般說明

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

外觀

Lyophilized from 0.2 μm-filtered solution in PBS.

重構

Reconstitute at 100 μg/mL in sterile PBS.

其他說明

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable