R2533

RS-127445 hydrochloride

≥98% (HPLC), powder

• 同義詞: 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
• 經驗公式（希爾表示法）: C₁₇H₁₆FN₃ · HCl
• CAS號碼: 199864-86-3
• 分子量：: 317.79
• MDL號碼: MFCD11112196
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329824019
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 儲存條件: desiccated
• 顏色: white to tan
• 溶解度: DMSO: ≥20 mg/mL
• 起源: Roche
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
• InChI: 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
• InChI 密鑰: MKJPYBJBPRFMHL-UHFFFAOYSA-N

描述

生化／生理作用

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

特點和優勢

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H319,H335
• 防範說明: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable