SRP8043

APRIL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• 同義詞: ACRP30headless:A-proliferation-inducing ligand, ACRP30headless:APRIL, ACRP30headless:CD256, TNFSF10
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: mouse
• 重組細胞: expressed in HEK 293 cells
• 籤條: FLAG^® tagged
• 化驗: >95% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: ~34 kDa by SDS-PAGE
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 雜質: <0.02 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: Q9D777
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: mouse ... Tnfsf13(69583)

描述

一般說明

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

外觀

Lyophilized from PBS.

重構

Reconstitute with 100 μL deionized water.

其他說明

The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG^®-tag.

法律資訊

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable