SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >90% (SDS-PAGE)

• 同義詞: AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: mouse
• 重組細胞: expressed in HEK 293 cells
• 籤條: FLAG^® tagged
• 化驗: >90% (SDS-PAGE)
• 形狀: liquid
• 分子量: ~22 kDa by SDS-PAGE
• 包裝: pkg of 50 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 濃度: ≥0.2 mg/mL
• 雜質: <0.1 EU/μg endotoxin, tested
• 顏色: clear
• UniProt登錄號: Q7TS55
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: mouse ... Tnfsf18(240873)

描述

一般說明

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

外觀

Solution in 10 mM glycine, pH 10.0.

其他說明

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

法律資訊

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable