SRP6282

Nicotinamide N-Methyltransferase (hNNMT) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• 同義詞: NNMT
• 分類程式碼代碼: 12352204
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥98% (SDS-PAGE)
• 形狀: liquid
• 分子量: 31.7 kDa (263 aa + NT 6xHis-tag)
• 包裝: pkg of 1 mg; pkg of 100 μg; pkg of 20 μg
• 濃度: 3.42 mg/mL
• UniProt登錄號: P40261
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... NNMT(4837)

描述

一般說明

N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. NNMT is an important cytosolic methyltransferase catalyzing the N-methylation of nicotinamide, pyridines and structural analogs, playing a crucial role in the biotransformation and detoxification of many xenobiotic compounds. In the N-methylation process, NNMT uses S-adenosyl methionine as the methyl donor and nicotinamide as methyl acceptor. NNMT is mostly expressed in the liver, and a lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. It may also play an important role in regulating biological processes related to N-methyl nicotinamide such as anti-inflammatory, anti-thrombotic, vasoprotective, and gastroprotective properties. Increased NNMT activity was reported in many kinds of tumors. NNMT is a potential biomarker and therapeutic target in caner diagnosis and treatment. NNMT serum levels have significance in the premature detection and in the management of patients with colorectal cancer. The recombinant protein includes hNNMT with N-terminal His-tag.

外觀

3.42 mg/mL solution in 25 mM Tris (pH8.0) buffer containing 20% glycerol.

安全資訊

• 儲存類別代碼: 13 - Non Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable