推薦產品
生物源
human
重組細胞
expressed in HEK 293 cells
籤條
6-His tagged (C-terminus)
化驗
≥92% (SDS-PAGE)
形狀
lyophilized powder
分子量
calculated mol wt 25.4 kDa
observed mol wt 28-33 kDa (DTT-reduced. Protein migrates due to glycosylation. Glu 19 is the predicted N-terminus.)
包裝
pkg of 10 μg
雜質
<1 EU/μg endotoxin (LAL test)
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... ADIPOQ(9370)
相關類別
一般說明
Adiponectin (also called Acrp30, AdipoQ) is an adipocyte specific secreted protein that circulates in the plasma. It is induced during adipocyte differentiation and its secretion is stimulated by insulin. The protein has a carboxyl-terminal globular domain and an amino-terminal collagen domain. The gene is mapped to human chromosome 3q27.
生化／生理作用
Adiponectin (ADIPOQ) has anti-atherosclerotic and anti-inflammatory properties. ADIPOQ has a role in physiological processes such as energy homeostasis and obesity. It exhibits anti-diabetic action by interacting with adiponectin receptors, AdipoR1 and AdipoR2. Low levels of adiponectin are also linked with hypertension and dyslipidemia. Mutation in the gene encoding it is linked with risk for endometrial cancer.
外觀
Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
重構
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Effects of MCF2L2, ADIPOQ and SOX2 genetic polymorphisms on the development of nephropathy in type 1 Diabetes Mellitus.
Zhang D, et al.
BMC Medical Genetics, 11, 116-116 (2010)
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Hotta K, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 20(6), 1595-1599 (2000)
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
Heid I M, et al.
Diabetes, 55(2), 375-384 (2006)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.
Kadowaki T, et al.
The Journal of Clinical Investigation, 116(7), 1784-1792 (2006)
Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer.
Bienkiewicz J, et al.
Pathology Oncology Research, 22(1), 135-138 (2016)
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